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Avanafil 200 mg, 100 mg, 50 mg - A Comprehensive Review
Content: Erectile dysfunction (ED) is an extremely common condition that affects approximately 30 million men in the United States alone. There are various treatment options available for ED, one of which is Avanafil, an orally administered, selective inhibitor of PDE5 (phosphodiesterase 5). It works in a similar fashion to sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra). However, Avanafil has a shorter duration of action compared to tadalafil.
Avanafil is available in several strengths including 50 mg, 100 mg and 200 mg. The recommended starting dose is 100 mg which is to be taken orally approximately 30 minutes prior to sexual activity. Based on individual efficacy and tolerability, the dose may be increased to a maximum of 200 mg or decreased to 50 mg. Avanafil should not be taken more frequently than once a day.
Avanafil starts working within 30 minutes to 1 hour of taking the medication, and the effects last up to 6 hours. Avanafil can be taken with or without food, but taking it with a high-fat meal may reduce the amount of drug that gets absorbed into the body.
Avanafil is not indicated for use in females. Geriatric use is not expected to have a significant impact on the pharmacokinetics of Avanafil. However, a dose reduction to 50 mg should be considered in patients 65 years of age and older.
Avanafil has been shown to have a rapid onset of action, with the majority of patients achieving a successful sexual intercourse attempt within 15 minutes of taking the drug. Across four major clinical trials involving more than 3,900 patients, Avanafil was shown to be effective in improving erectile function. In these trials, men taking Avanafil reported improved erections, and better overall sexual satisfaction.
Common side effects of Avanafil include headache, flushing, nasal congestion, nausea, and back pain. These side effects are generally mild to moderate in severity and transient. Serious side effects of Avanafil are rare. However, Avanafil may cause QT prolongation, which can sometimes progress to Torsade de Pointes (a life-threatening heart rhythm). Coadministration of Avanafil with medicines such as macrolide or fluoroquinolone antibiotics, azole antifungal agents, and antiretroviral protease inhibitors should be avoided.
Concomitant use of Avanafil with alpha-blockers, other PDE5 inhibitors, and strong CYP3A4 inhibitors is contraindicated. It is important to discuss with your doctor about all the medications you are taking, including prescription and over-the-counter medications, vitamins and herbal supplements.
Avanafil may cause dizziness, lightheadedness, or fainting. Rise slowly from a sitting or lying down position. Avoid driving or hazardous activities after taking Avanafil. Limit alcohol intake, as excessive alcohol use can increase the risk of fainting, dizziness, and low blood pressure.
To determine the appropriate dosage of Avanafil, it is crucial to consult with your healthcare provider. You can order Avanafil online from legitimate online pharmacies at competitive prices. It is however important to ensure that you are buying from a trusted online pharmacy to avoid counterfeit medications.
In conclusion, Avanafil is an effective treatment for ED with a rapid onset of action and a favorable safety profile. While it is widely available in various strengths, it is important to consult with your healthcare provider to determine the appropriate dosage for your individual needs.
This article does not provide medical advice. If you have any further questions, please consult with your healthcare provider.
Table 1: Strengths and Typical Doses of Avanafil
| Strength | Dose |
|---|---|
| 50 mg | Recommended starting dose for patients 65 years of age and older |
| 100 mg | Recommended starting dose |
| 200 mg | Maximum recommended dose |
Table 2: Advantages of Avanafil Compared to Other PDE5 Inhibitors
| Advantage | Avanafil | Sildenafil | Tadalafil | Vardenafil |
|---|---|---|---|---|
| Onset of Action | 15-30 minutes | 30-60 minutes | 2 hours | 25-60 minutes |
| Duration of Action | 4-6 hours | 4-6 hours | 24-36 hours | 4-6 hours |
| Food Interactions | No | Yes | Yes | Yes |
| Dose Frequency | Once a day | Once a day | Once a day | Once a day |
List 1: Indications for Avanafil Use
• Erectile dysfunction (impotence) • Pulmonary arterial hypertension
List 2: Contraindications for Avanafil Use
• Known hypersensitivity to any component of the tablets • Use of nitrates in any form, either regularly or intermittently • Use of alpha blockers other than 0.4 mg once daily tamsulosin • Use of strong CYP3A4 inhibitors (e.g., ketoconazole) • United States: Use of riociguat • Canada: Use of riociguat or nitrate medications • Patients with a known history of priapism • Patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease) • Patients with a history of non-arteritic anterior ischaemic optic neuropathy (NAION) • Patients with retinitis pigmentosa • Patients with severe hepatic impairment • Patients with severe renal impairment requiring dialysis
List 3: Side Effects of Avanafil
Uncommon (≥1/1,000 to <1/100):
• Blurred vision • Sensitivity to light • Redness of the eye • Abnormal sensation in the eye • Conjunctival hyperaemia • Ocular hyperaemia • Visual disturbance • Nasal congestion • Nasal oedema • Nasopharyngitis
Common (≥1/100 to <1/10):
• Headache • Dizziness • Flushing • Nasopharyngitis • Nausea • Back pain • Dyspepsia • Oropharyngeal pain • Sinus congestion • Upper abdominal pain
Rare (≥1/10,000 to <1/1,000):
• Angioedema • Orthostatic hypotension • Torsade de Pointes • Ventricular arrhythmia • Ventricular fibrillation • Ventricular tachycardia • Myocardial infarction • Cerebrovascular accident • Transient ischaemic attack • Seizure • Seizure recurrence • Epistaxis • Eye pain • Increased intraocular pressure • Retinal artery occlusion • Retinal vein occlusion • Visual field defect • Diplopia • Increased lacrimation • Abnormal vision • Chest pain • Tachycardia • Palpitations • Atrial fibrillation • Ventricular extrasystoles • Abdominal pain • Diarrhea • Dysphagia • Gastritis • Gastrooesophageal reflux disease • Gingivitis • Glossitis • Toothache • Abdominal discomfort • Abdominal distension • Dry mouth • Halitosis • Increased salivation • Lip dry • Stomatitis • Tongue ulceration • Back strain • Increased creatine phosphokinase in blood • Muscle spasms • Myalgia • Pain in extremity • Decreased appetite • Fluid retention • Gynaecomastia • Hyperhidrosis • Hot flush • Lethargy • Chills • Feeling abnormal • Chest discomfort • Feeling drunk • Feeling jittery • Irritability • Libido decreased • Mood swings • Panic attack • Restlessness • Sleep disorder • Snoring • Stress • Tightness of chest • Tremor • Vaginal haemorrhage • Vaginal infection • Asthenia • Fatigue • Feeling unwell • Pain • Pyrexia • Sudden cardiac death
List 4: Drug Interactions with Avanafil
Strong CYP3A4 Inhibitors:
• Ketoconazole (and other azole antifungals) • Itraconazole • Ritonavir • Indinavir • Saquinavir • Telithromycin • Nefazodone • Clarithromycin • Atazanavir • Delavirdine • Voriconazole • Grapefruit juice (large amounts)
Moderate CYP3A4 Inhibitors:
• Erythromycin • Fluconazole • Amprenavir • Fosamprenavir • Aprepitant • Diltiazem • Verapamil • Fluoconazole • Isradipine • Nicardipine • Quinidine • Amlodipine • Ranolazine • Nefazodone
CYP3A4 Inducers:
• Phenobarbital • Phenytoin • Carbamazepine • Rifampin • St John's Wort
Alpha-Blockers:
• Doxazosin • Tamsulosin • Terazosin • Alfuzosin • Silodosin • Prazosin
Riociguat:
• Adempas
Nitrates:
• Nitroglycerin • Isosorbide dinitrate • Isosorbide mononitrate • Amyl nitrate • Butyl nitrate • Isobutyl nitrate • Pentyl nitrate • Erythrityl tetranitrate • Pentaerythritol tetranitrate • Methylene blue