Fluconazole

Fluconazole: Everything You Need to Know Article Overview
This article will cover the key aspects of fluconazole, a popular antifungal medication used to treat fungal infections. We'll examine its uses, side effects, interactions, dosage information and ordering options. A table summarizing the key points will be included at the end.

What is Fluconazole? Fluconazole is a prescription antifungal medicine sold under the brand name Diflucan. It works by inhibiting the production of ergosterol, a chemical that fungi need to form their cell membranes. Without ergosterol, the fungal cell membrane becomes weakened and leaks, ultimately causing the fungal cell to die. Fluconazole is available in tablet or liquid form for oral use, as well as an injectable solution.

Uses of Fluconazole Fluconazole is used to treat a variety of fungal infections, including:

• Vulvovaginal candidiasis (yeast infection)
• Oropharyngeal and esophageal candidiasis
• Cryptococcal meningitis
• Prophylaxis to prevent fungal infections in patients with HIV/AIDS
• Invasive candidiasis, including candidemia, disseminated candidiasis and pneumonia
• Candida osteoarticular infections, including osteomyelitis, septic arthritis, and complex visceral fungal infections

Dosages of Fluconazole The dosage of fluconazole depends on the specific condition being treated and the patient's weight. Typical dosages include:

• Vulvovaginal candidiasis: a single dose of 150 mg
• Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily
• Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily for 14-21 days
• Systemic candidiasis: Loading dose of 800 mg (400 mg x 2) on the first day, followed by 400 mg once daily
• Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily for 10-12 weeks

Side Effects of Fluconazole
The most common side effects of fluconazole are:

• Nausea
• Headache
• Abdominal pain
• Diarrhea
• Dizziness
• Rash

Less common side effects include:

• Vomiting
• Increased liver enzymes
• Dark urine
• Taste changes
• Fatigue

Very rare but serious side effects include:

• Severe rash
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Anaphylaxis
• Angioedema
• Cholestasis and fulminant hepatic failure

Interactions with Fluconazole Fluconazole can interact with a number of other medications, including:

• Warfarin and other coumarin anticoagulants
• Phenytoin
• Cyclosporine
• Zidovudine
• Theophylline
• Rifampin
• Tacrolimus
• Sirolimus
• Rifabutin
• HMG-CoA reductase inhibitors (statins)
• Pimozide
• Quetiapine
• Erythromycin
• Amiodarone
• Voriconazole

Ordering Fluconazole Fluconazole is available by prescription only. To order fluconazole, you'll need to consult with a doctor or other qualified healthcare provider. They will assess your condition and provide a prescription if appropriate. You can then fill your prescription at a local pharmacy or via an online pharmacy that accepts prescription orders. Some common online sources for fluconazole include:

• Online pharmacies like Walgreens, CVS, Rite Aid
• Discount pharmacies like Costco
• Online prescription services like Express Scripts
• International pharmacies (be cautious of scams and ensure the pharmacy is reputable)

Key Points Summary Table