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Vastarel 20mg - Everything You Need to Know Vastarel 20mg is a prescription medication used to treat various cardiovascular conditions, including peripheral artery disease, intermittent claudication, and stable angina pectoris. It contains the active ingredient trimetazidine, which works by increasing oxygen delivery to the heart and improving glucose metabolism in ischemic (oxygen-deprived) tissues.
In this article, we'll delve into the details of Vastarel 20mg, including its uses, dosage, side effects, drug interactions, and how to buy it safely online.
Uses and Mechanism of Action Vastarel 20mg is primarily used to treat the following conditions:
Trimetazidine, the active ingredient in Vastarel 20mg, works by:
Overall, trimetazidine helps improve the heart's ability to tolerate ischemia and reduces symptoms of angina pectoris.
Dosage and Administration The recommended dosage of Vastarel 20mg is one 20mg tablet taken twice daily, in the morning and evening, during meals. The duration of treatment depends on the underlying condition and patient response.
In patients with severe renal impairment (creatinine clearance <30 ml/min), the dosage may need to be reduced to one 20mg tablet daily. However, there is no specific dosage recommendation for patients with hepatic impairment.
Side Effects Like all medications, Vastarel 20mg can cause side effects, which are generally mild and temporary. Common side effects (affecting up to 1 in 10 patients) include:
Less common side effects (affecting up to 1 in 100 patients) may include:
Rare side effects (affecting up to 1 in 1,000 patients) may include:
Very rare side effects (affecting up to 1 in 10,000 patients) may include:
If you experience any side effects, consult your doctor or pharmacist. They may adjust your dosage or recommend alternative treatments.
Drug Interactions Vastarel 20mg may interact with other medications, potentially affecting their efficacy or increasing the risk of side effects. It's essential to inform your doctor about all medications you're currently taking, especially:
Your doctor will assess the potential risks and benefits of concomitant therapy and adjust your medications accordingly.
Contraindications and Precautions Vastarel 20mg is contraindicated in patients with:
Use with caution in patients with:
Pregnancy and Breastfeeding There are limited data on the use of Vastarel 20mg in pregnant women. Animal studies have shown embryotoxicity at high doses. As a precautionary measure, Vastarel 20mg should be used during pregnancy only if clearly needed.
It is not known whether trimetazidine is excreted in human milk. However, as with other medications, breastfeeding should be discontinued during treatment with Vastarel 20mg.
Overdose There have been few reported cases of trimetazidine overdose. Symptoms may include:
In case of overdose, supportive measures should be instituted, and gastric lavage may be considered if the ingestion was recent. Activated charcoal could be administered if the patient is conscious. Hemodialysis is not expected to be of benefit due to the high protein binding and large volume of distribution of trimetazidine.
Buying Vastarel 20mg Online While Vastarel 20mg is available in some countries as a prescription medication, it may not be readily accessible in all areas. Buying medications online can be a convenient option, but it's crucial to do so safely to avoid counterfeit or ineffective products.
To buy Vastarel 20mg online, follow these steps:
Remember, buying medications online should always be done with caution and under the guidance of a healthcare professional.
Conclusion Vastarel 20mg is a valuable treatment option for patients with peripheral artery disease, intermittent claudication, and stable angina pectoris. It works by improving glucose metabolism and reducing oxygen consumption in the heart, alleviating symptoms and improving exercise tolerance.
While Vastarel 20mg is generally well-tolerated, it can cause side effects, including gastrointestinal disturbances, headaches, and dizziness. Rare but serious side effects may include anaphylactic reactions and blood disorders. Patients should inform their doctor about all medications they're taking, as concomitant use may interact with Vastarel 20mg.
If you're considering buying Vastarel 20mg online, ensure you have a valid prescription and choose a reputable online pharmacy. Be cautious of online scams and discuss any concerns with your doctor or pharmacist.
By carefully evaluating the benefits and risks of Vastarel 20mg and following proper guidelines for online purchasing, patients can effectively manage their cardiovascular conditions and improve their quality of life.
References:
Title: Angina Attacks in Ischaemic Heart Disease (IHD) - Causes, Symptoms, Diagnosis and Treatment
Introduction: Ischaemic heart disease (IHD), also known as coronary artery disease (CAD), is a condition characterized by reduced blood flow to the heart muscles, causing the heart to receive insufficient oxygen. One of the most common presentations of IHD is angina pectoris, a feeling of tightness or pressure in the chest, often radiating to the arm, neck, jaw or back. Angina attacks occur when the demand for oxygen by the heart exceeds the supply due to narrowed or blocked coronary arteries. In this article, we will discuss the causes, symptoms, diagnosis and treatment of angina attacks in IHD patients.
Causes of Angina Attacks: Angina attacks are caused by a reduction in blood flow to the heart muscles, which reduces the oxygen supply. The most common cause is atherosclerosis, a condition in which plaque builds up in the coronary arteries, leading to narrowing or total blockage. Other risk factors that can contribute to angina attacks include:
• Smoking • High blood pressure • High cholesterol • Diabetes • Obesity • Sedentary lifestyle • Family history of IHD • Stress • Anemia • Thyrotoxicosis
Table 1: Risk Factors for Angina Attacks in IHD
| Risk Factor | Description |
|---|---|
| Smoking | Damages the inner lining of the coronary arteries |
| High Blood Pressure | Accelerates plaque build-up in the arteries |
| High Cholesterol | Contributes to plaque formation |
| Diabetes | Damages the blood vessels and accelerates atherosclerosis |
| Obesity | Increases the risk of high blood pressure, high cholesterol and diabetes |
| Sedentary Lifestyle | Increases the risk of obesity and high blood pressure |
| Family History | Genetic predisposition to IHD |
| Stress | Increases heart rate and blood pressure, reducing blood flow |
| Anemia | Reduces the oxygen-carrying capacity of the blood |
| Thyrotoxicosis | Increases the heart rate and oxygen demand |
Symptoms of Angina Attacks: The main symptom of an angina attack is chest pain, which is often described as a feeling of tightness, heaviness or pressure. The pain can also radiate to other areas, including:
• Left arm or shoulder • Right arm or shoulder • Neck and throat • Jaw • Back or abdomen • Pelvis or legs
The pain is usually triggered by physical activity, emotional stress or exposure to cold, and is relieved by rest or nitroglycerin. Other symptoms that may be present during an angina attack include:
• Shortness of breath (dyspnea) • Fatigue • Palpitations • Coughing or wheezing • Anxiety or panic
Table 2: Symptoms of Angina Attacks
| Symptom | Description |
|---|---|
| Chest Pain | Tightness, heaviness or pressure in the center of the chest |
| Radiation | Pain radiates to the arm, neck, jaw or back |
| Triggering Factors | Physical activity, emotional stress, exposure to cold |
| Relieving Factors | Rest, nitroglycerin |
| Other Symptoms | Shortness of breath, fatigue, palpitations |
Diagnosis of Angina Attacks: The diagnosis of angina attacks is based on the patient's history, physical examination and various investigations. The following are the common methods used to diagnose angina:
Treatment of Angina Attacks: The treatment of angina attacks aims to reduce the frequency and severity of attacks, improve quality of life and reduce the risk of complications such as heart attack and heart failure. The following are the common treatment options:
Lifestyle Changes: • Quit smoking • Exercise regularly • Lose weight • Manage stress • Eat a heart-healthy diet • Limit alcohol consumption • Manage underlying conditions like diabetes and high blood pressure
Medications: • Nitrates (nitroglycerin, isosorbide mononitrate): Relaxes the blood vessels and reduces the heart's workload • Beta-Blockers (metoprolol, atenolol): Slows the heart rate and reduces blood pressure • Calcium Channel Blockers (amlodipine, verapamil): Relaxes the blood vessels and slows the heart rate • Ranolazine: Reduces the workload on the heart • ACE Inhibitors (lisinopril, ramipril): Relaxes the blood vessels and reduces the workload on the heart
Angioplasty and Stenting: Uses a balloon-tipped catheter to widen the narrowed coronary arteries and inserts a stent to keep them open.
Coronary Artery Bypass Grafting (CABG): Creates a detour around the blocked coronary arteries using a graft from another artery or vein.
Table 3: Treatment Options for Angina Attacks
| Treatment Option | Description |
|---|---|
| Lifestyle Changes | Quit smoking, exercise regularly, lose weight, manage stress, eat a heart-healthy diet |
| Nitrates | Relaxes the blood vessels and reduces the heart's workload |
| Beta-Blockers | Slows the heart rate and reduces blood pressure |
| Calcium Channel Blockers | Relaxes the blood vessels and slows the heart rate |
| Ranolazine | Reduces the workload on the heart |
| ACE Inhibitors | Relaxes the blood vessels and reduces the workload on the heart |
| Angioplasty and Stenting | Widens the narrowed coronary arteries using a balloon-tipped catheter and a stent |
| CABG | Creates a detour around the blocked coronary arteries using a graft |
Frequently Asked Questions: Q1. What is the difference between angina and a heart attack? A1. Angina is a feeling of tightness or pressure in the chest due to reduced blood flow, while a heart attack occurs when the blood flow is completely blocked, leading to damage or death of the heart muscles.
Q2. Can angina be prevented? A2. While angina cannot be completely prevented, the risk can be reduced by maintaining a healthy lifestyle, managing underlying conditions and controlling risk factors such as smoking, high blood pressure and high cholesterol.
Q3. How long do angina attacks last? A3. Angina attacks typically last for 5-15 minutes and are relieved by rest or nitroglycerin. If the pain lasts longer than 20 minutes or is not relieved by rest or medication, it may be a sign of a heart attack.
Q4. Can angina attacks be fatal? A4. Angina attacks themselves are not fatal, but they can increase the risk of heart attack and heart failure if left untreated. It is important to seek medical attention if the symptoms worsen or if there are signs of a heart attack, such as sudden severe chest pain, difficulty breathing or collapse.
Conclusion: Angina attacks are a common presentation of ischaemic heart disease, caused by reduced blood flow to the heart muscles due to narrowed or blocked coronary arteries. The symptoms include chest pain or tightness that may radiate to other areas and are triggered by physical activity or emotional stress. The diagnosis is based on the patient's history, physical examination and various investigations such as ECG, ETT and cardiac catheterization. The treatment aims to reduce the frequency and severity of attacks, improve quality of life and reduce the risk of complications, and includes lifestyle changes, medications and revascularization procedures such as angioplasty and CABG. With proper management, most patients with angina can lead active and productive lives.